TREATMENT OF COGNITIVE DISORDER IN THE ELDERLY: MILD COGNITIVE IMPAIRMENT AND DEMENTIA

Authors

  • Sara GONZÁLEZ FERNÁNDEZ
  • Manuel Jesús PÉREZ BAENA
  • Marina HOLGADO-MADRUGA

DOI:

https://doi.org/10.47743/asas-2022-1-681

Abstract

The best socio-sanitary conditions of the 21st century lead to an aging of society. In advanced age, the appearance of cognitive deterioration is more frequent, which raises the need to design therapeutic strategies to mitigate it. In addition to drug treatment, there are other interventions such as the type of diet, cognitive training, music therapy, acupuncture, physical exercise, etc. Due to the scientific evidence and the ease of practicing physical exercise as a therapeutic intervention, we propose to carry out a systematic bibliographic review on this treatment.

Therefore, our objective is to study the efficacy of physical exercise in mild cognitive impairment and dementia.

To this end, a systematic literature search was carried out in PubMed database using the MeSH terms: „Cognitive Dysfunction”, „Dementia”, „Alzheimer Disease”, „Therapeutics”, „Exercise”, „Exercise Therapy” and „Aged”.

We define efficacy in terms of improvement in global cognitive status or by cognitive domains after the application of the intervention with physical activity and by applying different scales to assess cognition.

It is concluded that aerobic physical activity is the most effective treatment for both mild cognitive impairment and dementia, the most favored cognitive domains being memory, global cognition and executive function. This therapy involves few adverse effects. More randomized controlled studies are needed in order to provide more scientific evidence for these results.

Author Biographies

Sara GONZÁLEZ FERNÁNDEZ

Doctor, Hospital Universitario de Salamanca, Salamanca, 37007, Spain

Manuel Jesús PÉREZ BAENA

Instituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, Salamanca, 37007, Spain.  Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain. 

Marina HOLGADO-MADRUGA

Departamento de Fisiología y Farmacología, Universidad de Salamanca, 37007, Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain. Instituto de Neurociencias de Castilla y León (INCyL), Salamanca, 37007, Spain.

References

Abril Carreres, M. A., Ticó Falguera, N., & Garreta Figuera, R. (2004). Enfermedades neurodegenerativas. Rehabilitación, 38(6), 318–324. https://doi.org/10.1016/s0048-7120(04)73487-8

Amjad, I., Toor, H., Niazi, I. K., Afzal, H., Jochumsen, M., Shafique, M., Allen, K., Haavik, H., & Ahmed, T. (2019). Therapeutic effects of aerobic exercise on EEG parameters and higher cognitive functions in mild cognitive impairment patients. The International Journal of Neuroscience, 129(6), 551–562. https://doi.org/10.1080/00207454.2018.1551894

Bademli, K., Lok, N., Canbaz, M., & Lok, S. (2019). Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial. Perspectives in Psychiatric Care, 55(3), 401–408. https://doi.org/10.1111/ppc.12324

Bisbe, M., Fuente-Vidal, A., López, E., Moreno, M., Naya, M., de Benetti, C., Milà, R., Bruna, O., Boada, M., & Alegret, M. (2020). Comparative Cognitive Effects of Choreographed Exercise and Multimodal Physical Therapy in Older Adults with Amnestic Mild Cognitive Impairment: Randomized Clinical Trial. Journal of Alzheimer’s Disease : JAD, 73(2), 769–783. https://doi.org/10.3233/JAD-190552

Broadhouse, K. M., Singh, M. F., Suo, C., Gates, N., Wen, W., Brodaty, H., Jain, N., Wilson, G. C., Meiklejohn, J., Singh, N., Baune, B. T., Baker, M., Foroughi, N., Wang, Y., Kochan, N., Ashton, K., Brown, M., Li, Z., Mavros, Y., … Valenzuela, M. J. (2020). Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI. NeuroImage. Clinical, 25, 102182. https://doi.org/10.1016/j.nicl.2020.102182

Brodziak, A., Wolińska, A., Kołat, E., & Różyk-Myrta, A. (2015). Guidelines for prevention and treatment of cognitive impairment in the elderly. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 585–597. https://doi.org/10.12659/MSM.892542

Cancela, J. M., Ayán, C., Varela, S., & Seijo, M. (2016). Effects of a long-term aerobic exercise intervention on institutionalized patients with dementia. Journal of Science and Medicine in Sport, 19(4), 293–298. https://doi.org/10.1016/j.jsams.2015.05.007

Cascaes da Silva, F., Beatriz Angélica Valdivia Arancibia, T., da Rosa Iop, R., Jose Barbosa Gutierres Filho, P., & da Silva, R. (2013). Escalas y listas de evaluación de la calidad de estudios científicos. Revista Cubana de Información En Ciencias de La Salud, 24(3), 295–312. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2307-21132013000300007& lng=es&nrm=iso&tlng=es

Choi, W., & Lee, S. (2019). The Effects of Virtual Kayak Paddling Exercise on Postural Balance, Muscle Performance, and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial. Journal of Aging and Physical Activity, 27(4), 861–870. https://doi.org/10.1123/japa.2018-0020

de Oliveira Silva, F., Ferreira, J. V., Plácido, J., Sant’Anna, P., Araújo, J., Marinho, V., Laks, J., & Camaz Deslandes, A. (2019). Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer’s disease: A randomized controlled trial. Maturitas, 126, 28–33. https://doi.org/10.1016/j.maturitas.2019.04.217

Diagn, C. (1923). American psychiatric association. In Archives of Neurology And Psychiatry (Vol. 9, Issue 5). https://doi.org/10.1001/archneurpsyc.1923.02190230091015

Distancia, M. A. Y. A. (n.d.). Evaluacion_multiaxial-with-cover-page-v2. 27–34.

Eshkoor, S. A., Hamid, T. A., Mun, C. Y., & Ng, C. K. (2015). Mild cognitive impairment and its management in older people. Clinical Interventions in Aging, 10, 687–693. https://doi.org/10.2147/CIA.S73922

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). „Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6

Fonte, C., Smania, N., Pedrinolla, A., Munari, D., Gandolfi, M., Picelli, A., Varalta, V., Benetti, M. V, Brugnera, A., Federico, A., Muti, E., Tamburin, S., Schena, F., & Venturelli, M. (2019). Comparison between physical and cognitive treatment in patients with MCI and Alzheimer’s disease. Aging, 11(10), 3138–3155. https://doi.org/10.18632/aging.101970

Garre-Olmo, J. (2018). [Epidemiology of Alzheimer’s disease and other dementias]. Revista de neurologia, 66(11), 377–386.

Ho, Rainbow T H, Fong, T. C. T., Chan, W. C., Kwan, J. S. K., Chiu, P. K. C., Yau, J. C. Y., & Lam, L. C. W. (2020). Psychophysiological Effects of Dance Movement Therapy and Physical Exercise on Older Adults With Mild Dementia: A Randomized Controlled Trial. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 75(3), 560–570. https://doi.org/10.1093/geronb/gby145

Ho, Rainbow Tin Hung, Cheung, J. K. K., Chan, W. C., Cheung, I. K. M., & Lam, L. C. W. (2015). A 3-arm randomized controlled trial on the effects of dance movement intervention and exercises on elderly with early dementia. BMC Geriatrics, 15, 127. https://doi.org/10.1186/s12877-015-0123-z

Hong, S.-G., Kim, J.-H., & Jun, T.-W. (2018). Effects of 12-Week Resistance Exercise on Electroencephalogram Patterns and Cognitive Function in the Elderly With Mild Cognitive Impairment: A Randomized Controlled Trial. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, 28(6), 500–508. https://doi.org/10.1097/JSM.0000000000000476

Lamb, S. E., Sheehan, B., Atherton, N., Nichols, V., Collins, H., Mistry, D., Dosanjh, S., Slowther, A. M., Khan, I., Petrou, S., & Lall, R. (2018). Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ (Clinical Research Ed.), 361, k1675. https://doi.org/10.1136/bmj.k1675

Langa, K. M., & Levine, D. A. (2014). The diagnosis and management of mild cognitive impairment: a clinical review. JAMA, 312(23), 2551–2561. https://doi.org/10.1001/jama.2014.13806

Law, L. L. F., Mok, V. C. T., & Yau, M. M. K. (2019). Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial. Alzheimer’s Research & Therapy, 11(1), 98. https://doi.org/10.1186/s13195-019-0548-2

Lin, C.-H., Chiu, S.-I., Chen, T.-F., Jang, J.-S. R., & Chiu, M.-J. (2020). Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model. International Journal of Molecular Sciences, 21(18), 6914. https://doi.org/10.3390/ijms21186914

López Locanto, Ó. (2015). Tratamiento farmacológico de la enfermedad de Alzheimer y otras demencias. Archivos de Medicina Interna, 37(2), 61–67. http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-423X2015000200003&lng=es&nrm=iso&tlng=es

Mandolesi, L., Polverino, A., Montuori, S., Foti, F., Ferraioli, G., Sorrentino, P., & Sorrentino, G. (2018). Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits. Frontiers in Psychology, 9, 509. https://doi.org/10.3389/fpsyg.2018.00509

Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x

Öhman, H., Savikko, N., Strandberg, T. E., Kautiainen, H., Raivio, M. M., Laakkonen, M.-L., Tilvis, R., & Pitkälä, K. H. (2016). Effects of Exercise on Cognition: The Finnish Alzheimer Disease Exercise Trial: A Randomized, Controlled Trial. Journal of the American Geriatrics Society, 64(4), 731–738. https://doi.org/10.1111/jgs.14059

Palau, F. G., Buonanotte, F., & Cáceres, M. M. (2015). From mild cognitive impairment to mild neurocognitive disorder: Progression of the clinical construct. Neurologia Argentina, 7(1), 51–58. https://doi.org/10.1016/j.neuarg.2014.08.004

Ramos Cordero, P., & Yubero, R. (2016). Tratamiento no farmacológico del deterioro cognitivo. Revista Espanola de Geriatria y Gerontologia, 51(Supl 1), 12–21. https://doi.org/10.1016/S0211-139X(16)30138-X

Rosen, W. G., Mohs, R. C., & Davis, K. L. (1984). A new rating scale for Alzheimer’s disease. The American Journal of Psychiatry, 141(11), 1356–1364. https://doi.org/10.1176/ajp.141.11.1356

Schwarz, S., Froelich, L., & Burns, A. (2012). Pharmacological treatment of dementia. Current Opinion in Psychiatry, 25(6), 542–550. https://doi.org/10.1097/YCO.0b013e328358e4f2

Toots, A., Littbrand, H., Boström, G., Hörnsten, C., Holmberg, H., Lundin-Olsson, L., Lindelöf, N., Nordström, P., Gustafson, Y., & Rosendahl, E. (2017). Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial. Journal of Alzheimer’s Disease : JAD, 60(1), 323–332. https://doi.org/10.3233/JAD-170014

Warburton, D. E. R., Nicol, C. W., & Bredin, S. S. D. (2006). Health benefits of physical activity: the evidence. CMAJ : Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne, 174(6), 801–809. https://doi.org/10.1503/ cmaj.051351

Yoon, D. H., Kang, D., Kim, H.-J., Kim, J.-S., Song, H. S., & Song, W. (2017). Effect of elastic band-based high-speed power training on cognitive function, physical performance and muscle strength in older women with mild cognitive impairment. Geriatrics & Gerontology International, 17(5), 765–772. https://doi.org/10.1111/ggi.12784

Zhu, Y., Wu, H., Qi, M., Wang, S., Zhang, Q., Zhou, L., Wang, S., Wang, W., Wu, T., Xiao, M., Yang, S., Chen, H., Zhang, L., Zhang, K. C., Ma, J., & Wang, T. (2018). Effects of a specially designed aerobic dance routine on mild cognitive impairment. Clinical Interventions in Aging, 13, 1691–1700. https://doi.org/10.2147/CIA.S163067

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Published

29-07-2022